Journal of the Chemical Society C: Organic

Synthesis and properties of 1, 3-diaza-1, 3-dihydro-2-phospholo (4, 5-d)-pyrimidine 2-oxides

JH Lister, GM Timmis

Index: Lister,J.H.; Timmis,G.M. Journal of the Chemical Society [Section] C: Organic, 1966 , p. 1242 - 1244

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Citation Number: 7

Abstract

Condensations of 4.5-diaminopyrimidines and phosphonic diamides in a high-boiling solvent produce diaza- phospholopyrirnidine oxides. These are hydrolytically unstable and give rise to derivatives of N-pyrimidinyl- phosphonarnidic acid. ... BECAUSE of the general similarity of the molecular architecture of 1,3-diaza-l,3-dihydro-2-phospholo(4,5d)- pyrimidine 2-oxides (111) to that of purine the possibility that such compounds might show antipurine activity ...