Condensations of 4.5-diaminopyrimidines and phosphonic diamides in a high-boiling solvent produce diaza- phospholopyrirnidine oxides. These are hydrolytically unstable and give rise to derivatives of N-pyrimidinyl- phosphonarnidic acid. ... BECAUSE of the general similarity of the molecular architecture of 1,3-diaza-l,3-dihydro-2-phospholo(4,5d)- pyrimidine 2-oxides (111) to that of purine the possibility that such compounds might show antipurine activity ...