Bioorganic & Medicinal Chemistry 2005-11-15

Tridemethylisovelleral, a potent cytotoxic agent.

Isabelle Aujard, Daniel Röme, Erwan Arzel, Martin Johansson, Dick de Vos, Olov Sterner

Index: Bioorg. Med. Chem. 13(22) , 6145-50, (2005)

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Abstract

The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaldehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral.