Mechanistic studies on type I and type II dehydroquinase with (6R)-and (6S)-6-fluoro-3-dehydroquinic acids

EJ Parker, CG Bello, JR Coggins, AR Hawkins…

Index: Parker, Emily J.; Bello, Concepcion Gonzalez; Coggins, John R.; Hawkins, Alastair R.; Abell, Chris Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 3 p. 231 - 234

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Citation Number: 13

Abstract

(6R)-and (6S)-6-Fluoro-3-dehydroquinic acids are shown to be substrates for type I and type II dehydroquinases. Their differential reactivity provides insight into details of the reaction mechanism and enables a novel enzyme-substrate imine to be trapped on the type I enzyme.