Molecular and Cellular Biochemistry 1979-05-06

Insulin sensitivity of liver glycogen synthase b into a conversion.

A H Gold, D Dickemper, D M Haverstick

Index: Mol. Cell Biochem. 25(1) , 47-59, (1979)

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Abstract

Liver glycogen synthase b phosphatase, chromatographically separable from phosphorylase a phosphatase, is decreased in 48-hour alloxan diabetic rats. The phosphatase activities are measured in an in vitro system using exogenous isolated phospho-enzyme as substrates with added phosphatases. Synthase and phosphorylase phosphatases were shown to have differential catalytic properties by their reactivity in the presence of Pi, the heat-stable inhibitor of phosphorylase phosphatase and after incubation with added cAMP-dependent protein kinase.