Chemical Communications 2012-01-07

Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides.

Ashish Thakur, Kainan Zhang, Janis Louie

Index: Chem. Commun. (Camb.) 48(2) , 203-5, (2012)

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Abstract

A protocol for the Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides that minimizes protodeboronation is described. A combination of catalytic amounts of Pd(OAc)(2) and SPhos in conjunction with CsF in isopropanol effectively affords a variety of coupled products. Surprisingly, a dramatic temperature dependence in product selectivity was observed.This journal is © The Royal Society of Chemistry 2012