Chemotherapy 1983-01-01

Terconazole - a new broad-spectrum antifungal.

J Van Cutsem, F Van Gerven, R Zaman, P A Janssen

Index: Chemotherapy 29(5) , 322-31, (1983)

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Abstract

Terconazole, a new triazole ketal, is found to be highly active in vitro on a wide range of yeasts and mycelium-forming fungi. The in vitro activity depends largely on the medium used. In vitro it is a potent antifungal agent in preventing the morphogenetic transformation of the yeast into the (pseudo-)mycelium form of Candida albicans. In vivo terconazole is highly active in topical treatment of various experimental models of dermatophytosis and candidosis. It also possesses moderate oral broad-spectrum activity. No side effects were observed.