Revue medicale de Liege 2005-11-01

[The calcipotriol-betamethasone dipropionate association].

F Henry, C Flagothier, P Delvoye, C Piérard-Franchimont, G E Piérard

Index: Rev. Med. Liege. 60(11) , 893-5, (2005)

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Abstract

The topical treatment of psoriasis benefits from the alternate use of dermocorticosteroids and vitamin D3 analogues. A new galenic formulation allows to combine them in a single application. Dovobet (LEO Pharma) ointment is the association of calcipotriol 50 microg/g with betamethasone dipoprionate 0.5 mg/g. This formulation boosts the therapeutic activity of calcipotriol. It also decreases the irritative inflammatory reaction due to calcipotriol without increasing the atrophogenic risk of the dermocorticoid.