Journal of Combinatorial Chemistry 2001-01-01

Solution-phase synthesis of an aminomethyl-substituted biaryl library via sequential amine N-alkylation and Suzuki cross-coupling.

M G Organ, E A Arvanitis, C E Dixon, D J Lavorato

Index: J. Comb. Chem. 3(5) , 473-6, (2001)

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Abstract

Described herein is the semiautomated preparation of a 20-member aminomethyl-substituted biaryl library. The two-step solution-phase synthesis was achieved via sequential N-alkylation of various amines with either 3- or 4-bromobenzyl bromide and Suzuki cross-coupling of the resultant aryl bromides with various boronic acids.