Bioorganic & Medicinal Chemistry Letters 2001-04-23

1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors.

A L Sabb, R L Vogel, M G Kelly, Y Palmer, D L Smith, T H Andree, L E Schechter

Index: Bioorg. Med. Chem. Lett. 11(8) , 1069-71, (2001)

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Abstract

Amino acid derivatives of 1,2,5-thiadiazol-3-yl-piperazine related to (+)-WAY-100135 and WAY-100635 are potent 5-HT1A receptor agonists and antagonists, which have selective affinity for 5-HT1A receptors versus alpha1 and dopamine (D2, D3, and D4) receptors.