Neuroscience Letters 2013-05-10

Peripheral group II and III metabotropic glutamate receptors in the knee joint attenuate carrageenan-induced nociceptive behavior in rats

Kyu Sang Lee, Eui Ho Park, Hwi-young Cho, Yang In Kim, Hee Chul Han

Index: Neurosci. Lett. 542 , 21-5, (2013)

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Abstract

• We evaluated effects of peripheral group II and III mGluR on arthritic pain of rats. • Pain behavior is relevant with reduced weight bearing and mechanical hyperalgesia. • Pre-treatment of group II and III mGluR agonist attenuated nociceptive behavior. • Post-treatment of group II and III mGluR agonist attenuated nociceptive behavior.