Nonactin biosynthesis: the initial committed step is the condensation of acetate (malonate) and succinate

ME Nelson, ND Priestley

Index: Nelson, Michael E.; Priestley, Nigel D. Journal of the American Chemical Society, 2002 , vol. 124, # 12 p. 2894 - 2902

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Citation Number: 37

Abstract

Nonactin is a macrotetrolide antibiotic produced by Streptomyces griseus subsp. griseus ETH A7796 that has shown activity against the P170-glycoprotein efflux pump associated with multiple drug resistant cancer cells. Nonactin is a polyketide, albeit a highly atypical one. The structure is composed of two units of each of the enantiomers of nonactic acid, arranged in a macrocycle, so that the molecule has S4 symmetry and is achiral. The ...