Chemical Communications 2013-04-21

Resonance Raman scattering of catalytic beacons for DNA detection.

Kristy S McKeating, Duncan Graham, Karen Faulds

Index: Chem. Commun. (Camb.) 49(31) , 3206-8, (2013)

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Abstract

A novel method for analysing the catalytic action of a DNAzyme is reported. Resonance Raman scattering (RRS) is shown to successfully monitor the oxidation of two different peroxidase substrates and has been implemented in an assay for the detection of target DNA, providing a more sensitive method of analysis than current colorimetric techniques.