Toxicology in Vitro 2011-12-01

Study of embryotoxicity of Fusarium mycotoxin butenolide using a whole rat embryo culture model

Jun Guo, Li-Shi Zhang, Yi-Mei Wang, Chang-Hui Yan, Wen-Peng Huang, Jing Wu, Hai-Tao Yuan, Bing-Wu Lin, Jun-Ling Shen, Shuang-Qing Peng

Index: Toxicol. In Vitro 25(8) , 1727-32, (2011)

Full Text: HTML

Abstract

Highlights ► The effects of butenolide on animal and human embryonic development are unknown. ► The embryotoxicity of butenolide is studied via an whole embryo culture model. ► Butenolide induces growth retardation and differentiation inhibition. ► The viability of 3T3-cell is impaired at 2.5mg/L, and the IC50 3T3 is 6.45mg/L. ► Butenolide exerts detrimental effects on rat embryo development in vitro.