Selective Inhibitors of Monoamine Oxidase. 4. 1 SAR of Tricyclic N-Methylcarboxamides and Congeners Binding at the Tricyclics' Hydrophilic Binding Site

M Harfenist, DM Joseph, SC Spence…

Index: Harfenist, Morton; Joseph, Diane M.; Spence, Sharon C.; Mcgee, Daniel P. C.; Reeves, Mark D.; White, Helen L. Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2466 - 2473

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Citation Number: 15

Abstract

Linear [6.6. 6] tricyclic moieties whose center ring is made of two atoms of differing size (here primarily thioxanth-9-ones and phenoxathiins) monosubstituted meta to the sulfur by C (O) NHMe include potent and selective inhibitors of monoamine oxidase A. Similarities with effects on SAR of acylamide and of diazapentacyclic substitution on such rings, including positional variables, the requirement for monomethylation (primary and dialkylated ...