ACS Combinatorial Science 2013-04-08

One-pot syntheses of isoquinolin-3-ones and benzo-1,4-diazepin-2,5-diones utilizing Ugi-4CR post-transformation strategy.

Chao Che, Song Li, Zhixiong Yu, Fangfang Li, Shengchang Xin, Liyan Zhou, Shuo Lin, Zhen Yang

Index: ACS Comb. Sci. 15(4) , 202-7, (2013)

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Abstract

One-pot and efficient syntheses of structurally diverse isoquinolin-3-ones and isoquinolin-3-one-based benzo-1,4-diazepin-2,5-diones have been developed. The notable features of the process include the Ugi condensation of monomasked phthalaldehydes with amines, carboxylic acids, and isonitriles, followed by HClO4-mediated intramolecular condensation of the carbonyl with amide.