Annales de Biologie Clinique 1990-01-01

Use of MagniSep chromium dioxide particles in an immunoassay system.

D M Obzansky, M C Connelly, E G Gorman, S J Zoha, C J Janes, B L Strasser, P M Tuhy

Index: Ann. Biol. Clin. (Paris.) 48(8) , 583-6, (1990)

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Abstract

The use of chromium dioxide particles as a solid support for very sensitive and rapid immunoassays, is the result of the combination of large surface area (40 m2) and high protein uptake capacity (40 mg/g) allowing rapid capture kinetics and high binding capacity. Magnetic and physical properties of these particles give a rapid separation, a complete resuspension and a rapid high-efficiency washing, highly desirable characteristics for efficient automation of immunoassays. Good precision and accuracy, exemplified by excellent recovery, parallelism and correlation were demonstrated. Test results prove that the technology is highly flexible and applicable to a variety of assay formats.