Organic Letters 2010-09-17

1,1-Dibromo-1-alkenes as valuable partners in the copper-catalyzed direct alkynylation of azoles.

Beatriz Pacheco Berciano, Sabrina Lebrequier, François Besselièvre, Sandrine Piguel

Index: Org. Lett. 12 , 4038, (2010)

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Abstract

The copper-catalyzed direct alkynylation of azoles with 1,1-dibromo-1-alkenes as electrophiles is described. These easily accessible substrates are a useful addition to the field of direct alkynylations in an efficient and functional group tolerant reaction to provide a straightforward entry to diverse alkynyl heterocycles.

Structure	Name/CAS No.	Molecular Formula	Articles
	Copper(I) bromide-dimethyl sulfide CAS:54678-23-8	C₂H₆BrCuS

Enantioselective Cu-catalyzed 1,4-addition of Grignard reage...
2008-01-01
[Angew. Chem. Int. Ed. Engl. 47 , 7718, (2008)]

[Organic Synth. 83 , 80, (2006)]

Rossiter, B. E. et al.B. E.; Swingle, N. M.
[Chem. Rev. 92 , 771, (1992)]

1,1-Dibromo-1-alkenes as valuable partners in the copper-catalyzed direct alkynylation of azoles.

Abstract

Related Compounds