Synlett

Synthesis of N-Alkoxyindol-2-ones by Copper-Catalyzed Intramolecular N-Arylation of Hydroxamates

T Kukosha, N Trufilkina, M Katkevics

Index: Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins Synlett, 2011 , # 17 p. 2525 - 2528

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Citation Number: 6

Abstract

Abstract The first example of copper-catalyzed intramolecular N-arylation of hydroxamic acid derivatives is presented. Based on this transformation a new method for the synthesis of N- alkoxyindol-2-ones from 2-(2-bromoaryl) acetylhydroxamates has been developed. The reaction conditions tolerate standard hydroxyl protecting groups on the hydroxylamine moiety and are also applicable for the synthesis of six-membered N-alkoxybenzolactams.