European Journal of Organic Chemistry

Highly Stereoselective and General Synthesis of (E)??Stilbenes and Alkenes by Means of an Aqueous Wittig Reaction

J McNulty, P Das

Index: McNulty, James; Das, Priyabrata European Journal of Organic Chemistry, 2009 , # 24 p. 4031 - 4035

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Citation Number: 51

Abstract

Abstract The chemoselective formation of trialkyl (benzylidene) ylides in water and their Wittig reaction with aromatic and aliphatic aldehydes provides a practical, stereoselective and environmentally benign route to valuable (E)-stilbenes and alkenes. The synthesis of the phytoalexin resveratrol is described. In addition, the method allows for a gram-scale synthesis of the anticancer agent DMU-212 utilizing no organic solvent at any stage.(© ...