Bioorganic & Medicinal Chemistry Letters 2013-12-01

Synthesis and evaluation of N-alkyl-S-[3-(piperidin-1-yl)propyl]isothioureas: High affinity and human/rat species-selective histamine H3 receptor antagonists

Shinya Harusawa, Koichi Sawada, Takuji Magata, Hiroki Yoneyama, Lisa Araki, Yoshihide Usami, Kouta Hatano, Kouichi Yamamoto, Daisuke Yamamoto, Atsushi Yamatodani

Index: Bioorg. Med. Chem. Lett. 23(23) , 6415-20, (2013)

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Abstract

OUP-186: histamine H3R antagonist inactive in rats, but especially potent in humans.