Bioorganicheskaia khimiia 1992-05-01

[Synthesis of oligodeoxyribonucleotides containing 5-fluoro-2'-deoxyribocytidine].

E A Kubareva, E A Romanova, T S Oretskaia, E S Gromova, Z A Shabarova

Index: Bioorg. Khim. 18(5) , 748-50, (1992)

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Abstract

A synthesis of the phosphoroamidite derivative of 5-fluoro-2'-deoxycytidine which allows one to introduce the modified nucleoside residue into the 5'-position of the oligodeoxyribonucleotide by the standard solid phase phosphoroamidite method, has been carried out. Oligonucleotides with 5-fluoro-2'-deoxycytidine residues in various positions of the DNA strand are obtained by the combination of chemical and enzymatic syntheses.