e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

New orally active PDE4 inhibitors with therapeutic potential

H Ochiai, A Ishida, T Ohtani, K Kusumi…

Index: Bioorganic and Medicinal Chemistry, , vol. 12, # 15 p. 4089 - 4100

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Citation Number: 24

Abstract

... Bioorganic & Medicinal Chemistry. ... b Development Planning, Ono Pharmaceutical Co., Ltd, 2-1-5 Doshomachi, Chuo-ku, Osaka 541-8526, Japan. Received 2 April 2004, Revised 24 May 2004, Accepted 24 May 2004, Available online 20 June 2004. Abstract. ...

1,3-Dimethyl-1H-pyrazol-5-amine Structure

1,3-Dimethyl-1H...

~%

4-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid Structure

4-Chloro-1,3-di...

DIETHYL 2-[[(1,3-DIMETHYL-1H-PYRAZOL-5-YL)AMINO]METHYLIDENE]MALONATE Structure

DIETHYL 2-[[(1,...

~%

4-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid Structure

4-Chloro-1,3-di...

1,3-Dimethyl-1H-pyrazol-5-amine Structure

1,3-Dimethyl-1H...

~%

ETHYL 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE Structure

ETHYL 4-CHLORO-...

Diethyl ethoxymethylenemalonate Structure

Diethyl ethoxym...

~%

ETHYL 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE Structure

ETHYL 4-CHLORO-...

1,3-Dimethyl-1H-pyrazol-5-amine Structure

1,3-Dimethyl-1H...

~%

4-chloro-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carbonyl chloride Structure

4-chloro-1,3-di...

ETHYL 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE Structure

ETHYL 4-CHLORO-...

~%

4-chloro-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carbonyl chloride Structure

4-chloro-1,3-di...

DIETHYL 2-[[(1,3-DIMETHYL-1H-PYRAZOL-5-YL)AMINO]METHYLIDENE]MALONATE Structure

DIETHYL 2-[[(1,...

~%

4-chloro-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carbonyl chloride Structure

4-chloro-1,3-di...

New orally active PDE4 inhibitors with therapeutic potential

[Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 29 - 32]