Abstract Starting with readily available aryl 4-substituted-1, 2, 3-thiadiazol-5-yl ketones, a series of 1-[(4-substituted-1, 2, 3-thiadiazol-5-yl) arylmethyl]-4-methylpiperazines was synthesized and tested for antihistaminic and anticholinergic activities. Four compounds were potent antihistamines, and two of these compounds displayed moderate anticholinergic activity.
