European Journal of Medicinal Chemistry 2008-06-01

Design and evaluation of anacardic acid derivatives as anticavity agents.

Ivan R Green, Felismino E Tocoli, Sang Hwa Lee, Ken-ichi Nihei, Isao Kubo

Index: Eur. J. Med. Chem. 43 , 1315-20, (2008)

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Abstract

On the basis of antibacterial anacardic acids, 6-pentadecenylsalicylic acids, isolated from the cashew apple, Anacardium occidentale L. (Anacardiaceae), a series of 6-alk(en)ylsalicylic acids were synthesized and tested for their antibacterial activity against Streptococcus mutans ATCC 25175. Among them, 6-(4',8'-dimethylnonyl)salicylic acid was found to exhibit the most potent antibacterial activity against this cariogenic bacterium with the minimum inhibition concentration (MIC) of 0.78 microg/ml.