Chemical Communications 2012-10-04

Facile synthesis of colorimetric histone deacetylase substrates.

Alexander Dose, Jan Oliver Jost, Antje C Spieß, Petra Henklein, Michael Beyermann, Dirk Schwarzer

Index: Chem. Commun. (Camb.) 48(76) , 9525-7, (2012)

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Abstract

Here we report a simple procedure for generating colorimetric histone deacetylase (HDAC) substrates by solid-phase peptide synthesis based on racemization-free couplings of amino acid chlorides. We demonstrate the applicability of these substrates in HDAC assays.