Syntheses of phenanthrene amino alcohols as antimalarials

L Krbechek, RR Riter, RG Wagner…

Index: Krbechek,L.O. et al. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 234 - 238

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Citation Number: 5

Abstract

. I\ veil--tirred niistiire of 2 1. of PhTu'O, and 900 g of AlC1, was cooled to'10'iii an ice bath. Starting at this temperature, 640 g 1. i nioi, ot'naphthalene and 320 g (3.2 mol) of succinic anhydride were added alternately over a period of about 5 min. The mixtiire w: t> kept in an ice bath for 2 hr and then poured onto a mixtiire cii ti kp of ice and 600 ml of concentrated HCl. The mixture xa? heated to 80-90", filtered, and allowed to cool to 30'. C'rade: j-(p- ...

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