The synthesis of 15-N-acetylglucosaminides of 15α-hydroxyestrone, 15α-hydroxyestradiol, and 15α-hydroxyestriol (estetrol) is described. The latter two were prepared by condensation of 2-acetamido-1α-chloro1, 2-dideoxy-3, 4, 6-trio-O-acetyl-d-glucopyranose with appropriately protected 15α-hydroxyestrogens by the Koenigs-Knorr reaction employing cadmium carbonate as a catalyst. Subsequent removal of protecting groups with ...
