… –activity relationships of 1, 3-diaryl 1, 2, 4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for …

P Hewawasam, M Erway, G Thalody, H Weiner…

Index: Hewawasam, Piyasena; Erway, Matthew; Thalody, George; Weiner, Harvey; Boissard, Christopher G.; Gribkoff, Valentin K.; Meanwell, Nicholas A.; Lodge, Nicholas; Starrett, Jr, John E. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1117 - 1120

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Citation Number: 32

Abstract

A series of 1, 3-diaryl 1, 2, 4-(4H)-triazol-5-ones was prepared and shown by electrophysiological analysis to activate a cloned maxi-K channel mSlo (or hSlo) expressed in Xenopus laevis oocytes. The effects of these structurally novel maxi-K channel openers on bladder contractile function were studied in vitro using isolated rat bladder strips pre- contracted with carbachol. Several 1, 3-diaryl 1, 2, 4-(4H)-triazol-5-one derivatives were ...