Bioorganic & Medicinal Chemistry Letters 2012-09-01

Important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against cisplatin-induced nephrotoxicity in LLC-PK1 cells.

Ji Hwan Lee, Woojung Lee, Seungyong Lee, Yujung Jung, Soon-Hye Park, Pilju Choi, Su-Nam Kim, Jungyeob Ham, Ki Sung Kang

Index: Bioorg. Med. Chem. Lett. 22(17) , 5475-9, (2012)

Full Text: HTML

Abstract

The aim of the present study was to verify the important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against oxidative stress-induced nephrotoxicity. The free radical-scavenging activity of ginsenoside Re-serine mixture was increased by heat-processing. Ginsenoside Re was transformed into less-polar ginsenosides such as Rg(2), Rg(6) and F(4) by heat-processing, and the glucose molecule at carbon-20 was separated. The improved-free radical-scavenging activity by heat-processing was mediated by the generation of antioxidant Maillard reaction products (MRPs) from the reaction of glucose with serine. Moreover, MRPs from ginsenoside Re-serine mixture showed protective effect against cisplatin-induced renal epithelial cell damage.Copyright © 2012 Elsevier Ltd. All rights reserved.