Tetrahedron Letters

7-Chloroquinoline: a versatile intermediate for the synthesis of 7-substituted quinolines

JJ Hirner, MJ Zacuto

Index: Hirner, Joshua J.; Zacuto, Michael J. Tetrahedron Letters, 2009 , vol. 50, # 35 p. 4989 - 4993

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Citation Number: 11

Abstract

A practical synthesis of 7-mono-substituted quinolines has been achieved. Selective reduction of the inexpensive commercial reagent 4, 7-dichloroquinoline affords 7- chloroquinoline, which has been converted into more complex 7-mono-substituted quinolines through a series of Pd-catalyzed cross coupling reactions. These studies include the first examples of Suzuki reactions for the preparation of 7-mono-substituted quinolines ...