Journal of Pharmacy and Pharmacology 1988-02-01

Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.

E A Formukong, A T Evans, F J Evans

Index: J. Pharm. Pharmacol. 40(2) , 132-4, (1988)

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Abstract

Tetrahydrocannabinol (THC) induced catalepsy in mice, whereas a cannabis oil (6.68% w/w THC), four cannabinoids and a synthetic mixture did not. Cannabinol (CBN) and olivetol inhibited THC-induced catalepsy in the mornings and the evenings, but cannabidiol (CBD) exhibited this effect only in the evenings. A combination of CBN and CBD inhibited THC-induced catalepsy equal to that of CBN alone in the mornings, but this inhibition was greater than that produced by CBN alone in the evenings.