Synthesis

Asymmetric Direct Michael Addition of Acetophenone to α, β-Unsaturated Aldehydes

W Li, W Wu, J Yang, X Liang, J Ye

Index: Synthesis, , # 7 p. 1085 - 1091

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Abstract

... [4] A catalytic asymmetric direct Michael reaction with atom economy would be more desirable in organic synthesis. ... higher chemoselectivities than those with electron-withdrawing groups, such as chloro or bromo (entries 5-7 and 13-16). ... 5-Oxo-5-phenyl-3- p -tolylpentanal (3c). ...