Life Sciences 2012-11-01

Clioquinol-induced increase and decrease in the intracellular Zn2+ level in rat thymocytes.

TomohiroM Oyama, Shiro Ishida, Yoshiro Okano, Hakaru Seo, Yasuo Oyama

Index: Life Sci. 91(23-24) , 1216-20, (2012)

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Abstract

Clioquinol is emerging as a potential therapy for some diseases, such as Alzheimer disease and cancer. This agent is a lipophilic chelator of Zn(2+). In this study, the effect of clioquinol on the intracellular Zn(2+) level was examined in order to gain insights into the toxicological profile of clioquinol.