Journal of the American Chemical Society

Oxazolidine hydrolysis. Participation of solvent and buffer in ring opening

TH Fife, L Hagopian

Index: Fife,T.H.; Hagopian,L. Journal of the American Chemical Society, 1968 , vol. 90, p. 1007 - 1014

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Citation Number: 31

Abstract

Abstract: The rates of hydrolysis of a series of 2-(substituted phenyl)-3-ethyloxazolidines have been determined in water, At high pH where the compounds are predominantly in the neutral form, the observed rate constants for aldehyde formation are nearly independent of pH and are correlated well with u, the value of p being-1.1. In moderately concentrated HCl solutions two reactions can be detected, a very rapid formation of an intermediate which ...