Bioorganic & medicinal chemistry

Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells

H Kim, M Kim, J Lee, H Yu, JM Hah

Index: Kim, Hyangmi; Kim, Minjung; Lee, Junghun; Yu, Hana; Hah, Jung-Mi Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 22 p. 6760 - 6767

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Citation Number: 5

Abstract

Recently, we have reported the syntheses and antiproliferative activities of N-(5-amino-1-(4- methoxybenzyl)-1H-pyrazol-4-yl amide derivatives on melanoma cells. As a continuous work for antiproliferative agents in melanoma, here we report the synthesis of conformationally rigid analogs, phenyl-6, 8-dihydropyrazolo [3, 4-b][1, 4] diazepin-7 (1H)- one derivatives 7a–g, 8a–o and their antiproliferative activities against A375P melanoma ...