Tetrahedron

Rh-catalyzed novel α-fluoroalkylation of α, β-unsaturated ketones and its mechanism

…, Y Ishida, E Murata, Y Oida, Y Mori, M Okawa, K Iwase…

Index: Sato, Kazuyuki; Ishida, Yoshitaka; Murata, Eriko; Oida, Yumiko; Mori, Yasumitsu; Okawa, Miho; Iwase, Kayoko; Tarui, Atsushi; Omote, Masaaki; Kumadaki, Itsumaro; Ando, Akira Tetrahedron, 2007 , vol. 63, # 51 p. 12735 - 12739

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Citation Number: 15

Abstract

Treatment of α, β-unsaturated ketones and fluoroalkyl halides with Et2Zn in the presence of RhCl (PPh3) 3 gave novel reductive fluoroalkylation products at the α-position of α, β- unsaturated ketones in moderate to good yields. The rhodium hydride complex derived from Et2Zn and Rh catalyst seems to have played an important role in this reaction.