3-(2-Carboxyindol-3-yl) propionic acid-based antagonists of the NMDA (N-methyl-D-aspartic acid) receptor associated glycine binding site

FG Salituro, BL Harrison, BM Baron…

Index: Salituro, Francesco G.; Harrison, Boyd L.; Baron, Bruce M.; Nyce, Philip L.; Stewart, Kenneth T.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1791 - 1799

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Citation Number: 64

Abstract

The role which the acidic amino acids glutamic acid and aspartic acid play as neurotransmitters in the mammalian central nervous system (CNS) has been intensely studied over the past several years. Several distinct receptor complexes have been defined by the ligands kainic acid (kainate), a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMF'A), and N-methyl-D-aspartic acid (NMDA). From a potential therapeutic point of view, ...