Synthesis of novel N-(2-hydroxy-2-p-tolylethyl)-amide and N-(2-oxo-2-p-tolylethyl)-amide derivatives and their antidyslipidemic and antioxidant activity

…, K Rajendar, S Sarkar, VK Singh, U Chaturvedi…

Index: Narender; Rajendar; Sarkar; Singh; Chaturvedi, Upma; Khanna; Bhatia Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6393 - 6397

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Citation Number: 8

Abstract

In continuation of our drug discovery program on metabolic diseases, we identified an alkaloidal amide, that is, Aegeline (V) from the plant Aegle marmelos leaves as a dual acting agent (antihyperlipidemic and antihyperglycemic). We therefore synthesized a series of alkaloidal amides [N-(2-hydroxy-2-p-tolylethyl)-amides and N-(2-oxo-2-p-tolylethyl)-amide derivatives] related to Aegeline and screened for their in vivo antihyperlipidemic activity in ...