Applied Radiation and Isotopes 2015-08-01

Fully automated production of sodium [(18)F]fluoride on AllInOne and miniAllInOne synthesizers.

Charlotte Collet, Muhammad Otabashi, Fabrice Giacomelli, Nicolas Veran, Gilles Karcher, Yves Chapleur, Sandrine Lamandé-Langle

Index: Appl. Radiat. Isot. 102 , 87-92, (2015)

Full Text: HTML

Abstract

A fully automated production of the imaging agent sodium [(18)F]fluoride ([(18)F]NaF) on two different modules commercialized by Trasis®, the AllInOne and the miniAllInOne, is reported. Both modules allow to prepare [(18)F]NaF in good radiochemical yield (around 97%) in less than 4min with the same specifications. Quality control of [(18)F]NaF produced by this way was performed according to the US and European Pharmacopeia monograph requirements. Copyright © 2015 Elsevier Ltd. All rights reserved.