Monoclonal antibodies in immunodiagnosis and immunotherapy 2015-08-01

A Versatile Monoclonal Antibody Specific Against Human DAB2IP.

Yintao Su, Fangyuan Shi, Zhanzhuang Zeng, Xiuling Wu, Yanhe Zhao, Lei Zhang, Zuofu Xie, Yunkun Wu

Index: Monoclon. Antib. Immunodiagn. Immunother. 34 , 246-50, (2015)

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Abstract

Human DAB2 interaction protein (DAB2IP) is a member of Ras-GTPase activating protein family and functions as a tumor suppressor, implying it could serve as a prognostic biomarker in cancers. Here we generated a mouse monoclonal antibody, 2A4, directed against human DAB2IP. This antibody was identified as IgG1 and specifically recognizes DAB2IP in both its native and denatured forms. It will serve as a useful and versatile tool for further mechanistic study and development of the potential prognostic significance of DAB2IP.