European Journal of Medicinal Chemistry 2012-08-01

Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: design, synthesis and biological evaluation.

Liqiao Shi, Rui Hu, Yanhong Wei, Ying Liang, Ziwen Yang, Shaoyong Ke

Index: Eur. J. Med. Chem. 54 , 549-56, (2012)

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Abstract

A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by (1)H NMR, (13)C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at μM level, which might be developed as novel lead scaffold for potential anticancer agents.Copyright © 2012 Elsevier Masson SAS. All rights reserved.