Carbohydrate Research 2001-01-01

Investigation of the complexation of albendazole with cyclodextrins for the design of new antiparasitic formulations

Bénédicte Pradines, Jean-François Gallard, Bogdan I. Iorga, Claire Gueutin, Philippe M. Loiseau, Gilles Ponchel, Kawthar Bouchemal

Index: Carbohydr. Res. 398 , 50-5, (2014)

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Abstract

Graphical abstract Representation of the complex between ABZ (cyan) and Me-β-CD (yellow) obtained by molecular docking (1:1 stoichiometry). Surfaces colored in yellow and cyan represent solvent accessible surfaces for Me-β-CD and ABZ, respectively. Views from the outside larger cavity of Me-β-CD (A and C), lateral view of ABZ/Me-β-CD inclusion complex (B), view from the narrow side of the Me-β-CD cavity (D) and detailed view highlighting the two hydrogen bonds observed between Me-β-CD and ABZ (E).