International Journal of Pharmaceutics 2015-02-20

Transport properties in aqueous ethambutol dihydrochloride.

Luís M P Veríssimo, Ana M T D P V Cabral, Francisco J B Veiga, Sara F G Almeida, M Luisa Ramos, Hugh D Burrows, M A Esteso, Ana C F Ribeiro

Index: Int. J. Pharm. 479(2) , 306-11, (2015)

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Abstract

Mutual diffusion coefficients, densities and viscosities are reported for aqueous solutions of ethambutol as its dihydrochloride (EMBDHC) at finite concentrations and at 298.15K. From these experimental results and by using the appropriate models (Stokes-Einstein and Hartley), the hydrodynamic radii Rh, the diffusion coefficient at infinitesimal concentration D(0) and the thermodynamic factors, FT, have been estimated, permitting us to have a better understanding of the transport behavior of ethambutol dihydrochloride in solution. Elucidation of lack of any possible drug-drug interactions in these systems was obtained by complementary (1)H nuclear magnetic resonance (NMR) spectroscopy data. Copyright © 2015 Elsevier B.V. All rights reserved.