Bioscience, Biotechnology, and Biochemistry 2008-03-01

Changes in the gene expression of C-myc and CD38 in HL-60 cells during differentiation induced by nicotinic acid-related compounds.

Chieri Ida, Shin Ogata, Katsuzumi Okumura, Hiroshi Taguchi

Index: Biosci. Biotechnol. Biochem. 72 , 868-871, (2008)

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Abstract

Changes in gene expression levels of c-myc and CD38 were examined during the differentiation of HL-60 cells to granulocytes due to three nicotinic acid-related compounds. CD38 expression was increased by isonicotinic acid and all-trans-retinoic acid (ATRA). Nicotinamide and nicotinamide N-oxide drastically decreased c-myc expression, but isonicotinic acid had no effect, suggesting that these compounds differentiate HL-60 to granulocytes through different pathways. These results should provide useful information as to the mechanisms of cell differentiation.