Bioscience, Biotechnology, and Biochemistry 2003-08-01

Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds.

Keiko Iwata, Shin Ogata, Katsuzumi Okumura, Hiroshi Taguchi

Index: Biosci. Biotechnol. Biochem. 67 , 1836-1839, (2003)

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Abstract

It was found that three niacin-related compounds, isonicotinic acid, nicotinamide, and nicotinamide N-oxide, induced granulocytic differentiation in HL-60 cells. We investigated the expression of CD38, which catalyzes the synthesis of cyclic ADP-ribose, a Ca2+ mobilizer, during differentiation by niacin-related compounds. It was found that CD38 was induced by isonicotinic acid, whereas nicotinamide and nicotinamide N-oxide containing an amino group did not induce it. The difference in expression of CD38 may provide some useful information for the elucidation of the mechanisms of cell differentiation.