Pharmazie 2002-04-01

Nonaqueous capillary electrophoretic analysis of hexetidine in a commercial liquid formulation.

A Jouyban, J Ye, B J Clark

Index: Pharmazie 57(4) , 248-9, (2002)

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Abstract

A non-aqueous capillary electrophoresis method has been proposed to analyse hexetidine and its degradation products in a commercial liquid pharmaceutical formulation. The separation was achieved using a 37 cm fused silica capillary with a 75 microns internal diameter, an electrolyte of 120 mM sodium acetate buffer in methanol, at 16 kV and 25 degrees C. The results show that the proposed method is able to resolve hexetidine from its degradation products and/or impurities.