Practical Cu (OAc) 2/TEMPO-catalyzed selective aerobic alcohol oxidation under ambient conditions in aqueous acetonitrile

…, JL Du, ZG Wang, ZN Zhang, X Xu, GL Zheng, YF Ji

Index: Jiang, Jian-An; Du, Jia-Lei; Wang, Zhan-Guo; Zhang, Zhong-Nan; Xu, Xi; Zheng, Gan-Lin; Ji, Ya-Fei Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1677 - 1681

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Citation Number: 12

Abstract

Abstract We reported a ligand-and additive-free Cu (OAc) 2/TEMPO catalyst system that enables efficient and selective aerobic oxidation of a broad range of primary and secondary benzylic alcohols, primary and secondary 1-heteroaryl alcohols, cinnamyl alcohols, and aliphatic alcohols to the corresponding aldehydes and ketones. This ambient temperature oxidation protocol is of practical features like aqueous acetonitrile as solvent, ambient air ...