Journal of Organic Chemistry 2003-12-12

N-tritylprolinal: an efficient building block for the stereoselective synthesis of proline-derived amino alcohols.

Joseph Bejjani, Fabrice Chemla, Max Audouin

Index: J. Org. Chem. 68(25) , 9747-52, (2003)

Full Text: HTML

Abstract

N-Tritylprolinal (prepared in four steps from l-proline) shows a very high Felkin diastereoselectivity in its reaction with various nucleophiles, leading to a straightforward and highly stereoselective access to syn-proline-derived amino alcohols.