Chemical Communications 2011-04-21

DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker.

Katarzyna Gorska, Alex Manicardi, Sofia Barluenga, Nicolas Winssinger

Index: Chem. Commun. (Camb.) 47(15) , 4364-66, (2011)

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Abstract

Nucleic acid templated reactions have attracted significant attention for nucleic acid sensing. Herein we report a general design which extends the potential of nucleic acid templated reactions to unleash the function of a broad diversity of small molecules such as a transcription factor agonist, a cytotoxic or a fluorophore.© The Royal Society of Chemistry 2011