Pathologie Biologie 1985-09-01

[Metabolism of antipyrine in man].

F Pautet, R Barret, M Daudon, B Mathian

Index: Pathol. Biol. 33(7) , 777-80, (1985)

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Abstract

Antipyrine is widely used as a model compound to assess the hepatic metabolism in man. This drug is extensively metabolized by the hepatic microsomal drug-oxidizing system, into three main metabolites and six minor compounds of the phase I. The metabolite fate of this drug is not fully understood. A new metabolite pathway including a ring opening seems possible.